I would suggest interviewees to maintain their cool and not to over react. Just think that your life is not going to end if you do not clear this interview. There is always a next time where you can prove yourself and get selected. The interviewer asks this question to see how you react to it. He is just checking your emotional balance. Few candidates burst at this declaration. Its always recommended that you maintain your calm. The interviewer wants to know how you react when adversity affects you or when you are unprepared to handle a failure.
You can answer this question by telling that there might be some gaps between the current requirement and your current qualifications but its ok and next time you will sharpen your skills and appear for interview. This is the positive answer to one of the negative question and it reflects your composed personality.
I would suggest candidates to remain cool when provoked by an interviewer. its no use reacting to situations. Sound professional and display matured personality to get selected.
I would request others to please add their valuable comment which will be helpful to the Interviewees.